Maximilian Fuetterer1, Christian Torben Stoeck1,2, and Sebastian Kozerke1,2
1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 2Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom
Second-order
motion compensation for PRESS (PRESSmc) is proposed to allow for
robust single-voxel cardiac spectroscopy throughout the entire cardiac cycle. Motion-compensated
spoiler gradients were designed and implemented into a cardiac-triggered PRESS sequence.
A numerical 3D model of cardiac motion was used to optimize and validate the
gradient waveforms. In-vivo measurements in healthy volunteers were obtained to
assess SNR and triglyceride-to-water ratio (TG/W). SNR gains and variability of
TG/W of PRESSmc were evaluated against a conventional PRESS sequence
with optimized gradients. PRESSmc effectively reduces cardiac-motion
induced signal degradation during FID spoiling providing higher SNR and less
variability for TG/W quantification.
