Abstract #1078

Multi-compartment microscopic diffusion anisotropy imaging brought into clinical practice

Enrico Kaden¹, Nathaniel D. Kelm², Robert P. Carson³, Mark D. Does², and Daniel C. Alexander¹

¹Centre for Medical Image Computing, University College London, London, United Kingdom, ²Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ³Departments of Neurology and Pediatrics, Vanderbilt University, Nashville, TN, United States

This work introduces a multi-compartment model for microscopic diffusion anisotropy imaging using an off-the-shelf pulse sequence achievable on standard clinical scanners. In particular, we will provide estimates of microscopic features specific to the intra- and extra-neurite compartments unconfounded by the effects of fibre crossings and orientation dispersion, which are ubiquitous in the brain. The new imaging technique is demonstrated in a large cohort of healthy young adults as well as for the detection of microstructural tissue alterations in a preclinical animal model of tuberous sclerosis complex.

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