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Abstract #1056

Deep subcutaneous adipose tissue lipid unsaturation associates with intramyocellular lipid content

Jesper Lundbom1,2, Alessandra Bierwagen1,2, Kálmán Bodis1,2, Jaakko Kaprio3,4,5, Aila Rissanen6,7, Nina Lundbom8, Michael Roden1,2,9, and Kirsi Pietiläinen4,6,10

1German Diabetes Center, Leibniz Center for Diabetes Research, Düsseldorf, Germany, 2German Center for Diabetes Research (DZD e.V.), Partner Düsseldorf, Düsseldorf, Germany, 3Finnish Twin Cohort Study, Department of Public Health, Hjelt Institute, Helsinki, Finland, 4FIMM, Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland, 5National Institute for Health and Welfare, Helsinki, Finland, 6Obesity Research Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland, 7Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland, 8HUS Medical Imaging Center, University of Helsinki, Helsinki, Finland, 9Department of Endocrinology and Diabetology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany, 10Endocrinology, Abdominal Center, Helsinki University Central Hospital, Helsinki, Finland

The present study uses non-invasive MRS to examine whether MZ twins discordant for BMI display depot specific differences in adipose tissue unsaturation (DSAT and SSAT), and how the unsaturation relates to body fat distribution and ectopic fat. The main finding of the twin study is that DSAT lipid unsaturation associates with intramyocellular lipid content, which was further confirmed in a general population study and for the repeated sampling of one volunteer. These results highlight the role of fatty acid composition in adipose tissue - skeletal muscle crosstalk.

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