Stephen J Sawiak1, Bianca Jupp1, Tom Taylor1, Daniele Caprioli1, T Adrian Carpenter1, and Jeffrey Dalley1
Disorders of impulse control are a rising
issue in society as diagnosis rates of conditions such as attention deficit and
hyperactivity disorder are increasing. In humans, the MEGAPRESS approach to
measuring GABA is becoming a standard technique but it has not yet been used
much in translational studies. Here, we used it to measure GABA in the striatum
of highly-impulsive rats compared to rats with low impulsivity and found
significantly reduced levels of this inhibitory neurotransmitter in the
impulsive animals.
