Veronica Clavijo Jordan 1, Su-Tang Lo1, Christian Preihs1, Sara Chirayil1, Wen-Hong Li1, Neil M Rofsky1, and Dean Sherry1,2
1UT Southwestern Medical Center, Dallas, TX, United States, 2UT Dallas, Richardson, TX, United States
The prostate has the
highest levels of Zn(II) in the organism and there are marked differences in content
between the healthy, malignant, and benign hyperplastic prostate. Given that
accurate differential diagnosis between these conditions is difficult
non-invasively, we introduce prostate Zn(II) as a MRI imaging biomarker. In
this work we use a Gd-based zinc sensor that can sensitively detect glucose-stimulated
intracellular release of Zn(II) in the healthy, and malignant mouse prostate
using a transgenic adenocarcinoma model.
