Evita Wiegers1, Kirsten Becker1, Hanne Rooijackers2, Cees Tack2, Arend Heerschap1, Bastiaan de Galan2, and Marinette van der Graaf1,3
1Radiology and Nuclear Medicine, Radboud umc, Nijmegen, Netherlands, 2Internal Medicine, Radboud umc, Nijmegen, Netherlands, 3Pediatrics, Radboud umc, Nijmegen, Netherlands
Hypoglycemia-induced
changes in global and regional cerebral blood flow (CBF) were investigated in
patients with type 1 diabetes (T1DM) and impaired (IAH) or normal awareness of
hypoglycemia (NAH) and in healthy subjects. CBF-weighted images were acquired using
pseudo-continuous arterial spin labeling MRI. Global CBF increased in response
to hypoglycemia in T1DM IAH subjects, but not in T1DM NAH or in healthy
controls. Hypoglycemia induced regional relative increases in CBF in the
thalamus of both T1DM NAH and healthy controls, and in the frontal lobes of
T1DM NAH, while no such increases were found in the T1DM IAH group.
