Xingxing Zhang1, Carson Ingo1, and Matthias J.P. van Osch1,2
1C. J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Leiden Institute for Brain and Cognition, Leiden, Netherlands
ASL-prepared IVIM is proposed to study the arterial IVIM signal as a function of post-labeling-delay. The D*-value as calculated from ASL-IVIM
decreases as a function of PLD, reaching a plateau for PLDs>2000ms. Signal
from conventional IVIM shows an intermediate D*-value corresponding to the
ASL-IVIM-signal for a PLD of ~1750ms indicating the IVIM signal does not only
originate from the microvasculature, but also includes vascular signal. The
alternative explanation of extravasation of labeled spins into the
extravascular compartment seems unlikely, since the observed D* at these PLDs are
still a factor 3~4 higher than the diffusion coefficient of the slow
compartment.
