Abstract #0983

Quantification of lung parenchyma perfusion in small animal imaging with Flow-sensitive Alternating Inversion Recovery (FAIR) 2D UTE

Marta Tibiletti¹, Andrea Bianchi², Detlef Stiller², and Volker Rasche^1,3

¹Core Facility Small Animal MRI, Ulm University, Ulm, Germany, ²Target Discovery Research, In-vivo imaging laboratory, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany, ³Department of Internal Medicine II, Ulm University, Ulm, Germany

Functional information of the lung is of great importance for staging and monitoring lung disease. In this context, perfusion is conventionally addressed by systemic injection of contrast agent (CA) with subsequent quantitatively monitoring of the wash-in of the CA, or more frequently qualitatively assessment of the lung intensity pattern during the CA steady-state phase. Especially in small animal imaging, quantification of the respective perfusion dynamics is difficult due to the rather coarse temporal resolution achievable. In this work, the application of the non-invasive FAIR technique is combined with a 2D UTE readout thus enabling non-invasive quantification of lung perfusion.

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