Abstract #0965

Evaluation of endothelial barrier function in atherosclerosis induced rabbits using S-nitroso human serum albumin (S-NO-HSA) - blood pool agent compound and dynamic contrast-enhanced (DCE)-MRI

Peter Opriessnig¹, Gunter Almer¹, Harald Froehlich¹, Claudia Cabella², Rudolf Stollberger³, Seth Hallstroem⁴, Gerd Hoerl⁴, and Harald Mangge¹

¹Clinical Institute for Medical and Chemical Laboratory Diagnosis, Medical University of Graz, Graz, Austria, ²CRB Bracco Imaging SpA, Colleretto Giacosa, Torino, Italy, ³Institute of Medical Engineering, Graz University of Technology, Graz, Austria, ⁴Institute of Physiological Chemistry, Medical University of Graz, Graz, Austria

Endothelial dysfunction plays a key role in the progression and pathogenesis of atherosclerosis (AS). DCE-MRI in combination with a special nitric oxide donor S-nitroso human serum albumin (S-NO-HAS) blood pool agent (B22956/1) compound could be an additional measure that provides information on the influence of plaque burden on the vascular permeability and vasomotion. In this work, we demonstrate the feasibility to investigate endothelial barrier function and NO induced endothelium-independent vasomotor response of the abdominal aorta in control and AS induced rabbits simultaneously. Relative vessel wall signal enhancement and change in lumen area were measured using a double-inversion-recovery turbo-spin-echo sequence.

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