Abstract #0960

DCE-MRI reveals more extensive vasa vasorum in patients with cardiovascular events

Huijun Chen¹, Juan Wang², Jie Sun³, Daniel S Hippe³, Xihai Zhao¹, and Hongbing Liu²

¹Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, People's Republic of, ²Cardiology, People’s Liberation Army General Hospital, Beijing, China, People's Republic of, ³Radiology, University of Washington, Seattle, WA, United States

Pharmacokinetic modeling of DCE-MRI can quantify the adventitial vasa vasorum of carotid atherosclerotic lesions using the transfer constant (K^trans). However, the relationship between the DCE-MRI quantified carotid adventitial vasa vasorum and cardiovascular events remains unclear. In this study, we found that the adventitial K^trans of carotid artery measured by DCE-MRI was associated with cardiovascular events (cerebral ischemic events and coronary artery events), suggesting that the carotid adventitial vasa vasorum is not merely a local risk factor but also a promising systemic marker for cardiovascular risk. DCE-MRI may be valuable for identifying high risk patients in clinical practice.

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