Evaluation of SLIce Dithered Enhanced Resolution Simultaneous MultiSlice (SLIDER-SMS) for human fMRI at 3T
An T. Vu1,2, Alex Beckett1, Kawin Setompop3, and David A. Feinberg1,2
1Helen Wills Neuroscience Institute, UC Berkeley, Berkeley, CA, United States, 2Advanced MRI Technologies, Sebastopol, CA, United States, 3Martinos Center for Biomedical Imaging, Charlestown, MA, United States
We evaluate the
synergistic combination of super-resolution and SMS for high-resolution
whole brain fMRI. We find that SLIDER-SMS can acquire high resolution,
high CNR fMRI data at 3T which is normally only acquired at 7T. The regularized
deblurring/reconstruction of SLIDER yielded 40% more BOLD CNR than normally
acquired high resolution (HR) data, while omitting the deblurring step
altogether yielded 100% more BOLD contrast with similar high k-space frequency
tSNR. Future use of SLIDER for fMRI may enable robust columnar level results at
3T and allow higher spatial resolution fMRI investigations at 7T than currently
possible.
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