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Abstract #0927

Microstructure models for diffusion MRI in breast cancer and surrounding stroma: an ex vivo study

Colleen Bailey1, Bernard Siow2, Eleftheria Panagiotaki1, John H Hipwell1, Sarah E Pinder3, Daniel C Alexander1, and David J Hawkes1

1Centre for Medical Image Computing, University College London, London, United Kingdom, 2Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, 3Breast Research Pathology, King's College London and Guy's Hospital, London, United Kingdom

A variety of one- and two-compartment models were fitted to rich diffusion data sets from ex vivo breast tissue samples containing tumour. Two compartment models with restriction explained the data better than conventional ADC and bi-exponential models, as determined by the Akaike Information Criterion. In four of seven samples, anisotropy was also observed, although parametric maps of the primary eigenvector direction show that regions of coherence are small (~1 mm diameter).

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