Abstract #0909

Correlations between cervicovaginal fluid metabolites and gestational age at delivery

Emmanuel Amabebe¹, Steven Reynolds², Victoria Stern¹, Jennifer Parker³, Graham Stafford³, Martyn Paley², and Dilly Anumba¹

¹Academic unit of Reproductive and Developmental Medicine, University of Sheffield, Sheffield, United Kingdom, ²Academic unit of Radiology, University of Sheffield, Sheffield, United Kingdom, ³School of Dentistry, University of Sheffield, Sheffield, United Kingdom

Magnetic Resonance Spectroscopy (¹H-MRS) can detect the metabolite profile of the vaginal microniche and reflects the vaginal bacterial community function. This study assessed the correlation between ¹H-MRS vaginal fluid metabolites and maternal parameters related to preterm birth. As expected, vaginal pH, fetal fibronectin, and cervical length correlated with gestational age at delivery (GAAD). Vaginal pH also correlated with lactate and acetate integrals in all study cohorts. Additionally, lactate and glutamine/glutamate integrals in women studied at 20-22 gestational weeks; and succinate/lactate ratio in women studied at 26-28 gestational weeks, correlated modestly with GAAD. Further correlations between metabolites were found.

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