1NMR, INMAS, DRDO, Delhi, Delhi, India, 2Neurobehavioral lab, INMAS, DRDO, Delhi, Delhi, India
Mild
traumatic brain injury (mTBI), (70-90% of all TBI) shows consequences of anxiety-like
behavioral alterations in approximately 23% of cases. The
present study assesses acute anxiety-like behavior and its neurometabolic basis
in a rodent model of mTBI using 1H-MRS and neurobehavioral
analysis. At day5 reduced Tau/tCr levels in cortex was observed in mTBI group
as compared to control. Neurobehavioral analysis showed increased anxiety-like
behavior with normal cognition at day5. This study provides a putative neurometabolic
basis of anxiety-like behavior in mTBI model which closely mimics human
concussion injury.
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