Abstract #0852

Quantitative measurements of the spinal cord blood flow of an animal model of relapsing-remitting MS.

Mohamed Tachrount¹, Andrew Davies², Roshni Desai², Kenneth Smith², David Thomas¹, and Xavier Golay¹

¹Dept. of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom, ²Dept. of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom

Perfusion-weighted imaging studies have demonstrated that there is a widespread cerebral hypoperfusion in patients with MS, regardless of the clinical subtype. The mechanism and the role of hypoxia are still unclear. The purpose of this work was to longitudinally investigate the SC blood flow (SCBF) during the different phases of disease progression in EAE rats using an optimized ASL technique. These measurements demonstrated for the first time on EAE animal model that the neurological deficits are strongly correlated with impaired blood flow.

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