Silvia Rizzitelli1, Stefan Glöggler1, Noël Pinaud1, Gerard Raffard1, Veronique Bouchaud1, Vanessa Zhendre1, Stephane Sanchez1, Alan Wong2, and Yannick Cremillieux1
1Centre de Resonance Magnétique des Systemes Biologiques, University of Bordeaux, Bordeaux, France, 2NIMBE/LSDRM, CEA-Saclay, Gif-sur-Yvette, France
The
challenge of this study was to investigate the ability of a custom-made 1H
microsolenoidal coil operating at 7T, with an inner volume of 1 μL, of visualizing the
on-line metabolism of brain metabolites through the use of a microdialysis
catheter, carried out with the complementarity of MRI and MRS techniques. 1H-MR
spectra of in vitro (human
gliobastoma cells) and in vivo
(healthy and glioblastoma-bearing rats) were acquired every 3.50 minutes to
monitor the real-time variations of metabolites concentration, after injection
of 13C labelled compunds.
