Abstract #0827

The potential of apparent diffusion coefficient in differentiating various sub-types of breast tumors and its association with hormonal status

Khushbu Agarwal¹, Rani Gupta Sah¹, Uma Sharma¹, Smriti Hari², Sandeep Mathur³, Vurthaluru Seenu⁴, Rajinder Parshad⁴, and Naranamangalam R Jagannathan¹

¹Department of NMR and MRI Facility, All India Institute of Medical Sciences, Delhi, India, ²Department of Radio-diagnosis, All India Institute of Medical Sciences, Delhi, India, ³Department of Pathology, All India Institute of Medical Sciences, Delhi, India, ⁴Department of Surgical Disciplines, All India Institute of Medical Sciences, Delhi, India

Potential of apparent diffusion coefficient (ADC) in differentiating various sub-types of malignant and benign breast tumors using diffusion weighted MRI and its association with different hormonal status in breast cancer patients was studied. A significantly lower ADC of malignant compared to benign and healthy breast tissues was observed. The ADC of fibroadenomas was lower compared to fibrocystic with fibroadenoma and cystic lesions and higher in cystic and fibrocystic lesions than benign ductal epithelial cells. No association of ADC with molecular biomarkers ER, PR and Her2neu was seen. Results showed the utility of ADC in differentiating various types of breast tissues.

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