Pinar Senay Özbay1,2, Lars Kasper2, Klaas Paul Pruessmann2, and Daniel Nanz1
1Department of Radiology, University Hospital Zurich, Zurich, Switzerland, 2Institute of Biomedical Engineering, ETH Zurich, Zurich, Switzerland
Functional-QSM, promises to offer quantitative
information more directly related to neuronal-activity than BOLD-fMRI and to
partially ameliorate the inherent problem of spatial mismatch between locations
of neuronal-activation and apparent BOLD-detected-activation. The data for fQSM
and fMRI can be simultaneously acquired and mostly processed with the
well-established fMRI toolchains. The current high-field study, evaluates
details of the processing-chain, provides clear evidence that fQSM is capable
(1) to detect neuronal-activation in well-resolved volumes that unambiguously
reside within grey-matter, even after removal of apparent activations
associated with larger-veins, and (2) to identify the visual-network in
resting-state-experiments, thus highlighting a considerable potential of fQSM.
