Abstract #0808

Transit time mapping in the mouse brain using time-encoded pCASL

Lydiane Hirschler^1,2,3, Leon P. Munting^4,5, Wouter M. Teeuwisse⁴, Ernst Suidgeest⁴, Jan M. Warnking^1,2, Matthias J. P. van Osch⁴, Emmanuel L. Barbier^1,2, and Louise van der Weerd^4,5

¹Grenoble Institut des Neurosciences, Université Grenoble Alpes, Grenoble, France, ²Inserm U836, Grenoble, France, ³Bruker Biospin, Ettlingen, Germany, ⁴Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁵Human Genetics, Leiden University Medical Center, Leiden, Netherlands

Arterial transit time (ATT) is known to influence CBF-quantification and is interesting in itself, as it may reflect underlying vascular pathologies. Currently, no MRI sequence exists to measure ATT in mice. Recently, time-encoded labeling schemes have been implemented in rats and men, enabling ATT-mapping with higher SNR and less scan-time than multi-delay ASL. In this study, we show that time-encoded pCASL (te-pCASL) enables transit times measurements in mice. Furthermore, ATT was found to be preserved in old WT mice.

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