Abstract #0791

Mapping the brain’s “Sheet Probability Index” (SPI) with diffusion MRI: Sheet happens?!

Chantal Tax^1,2, Tom Dela Haije³, Andrea Fuster³, Carl-Fredrik Westin², Max A. Viergever¹, Luc Florack³, and Alexander Leemans¹

¹Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands, ²Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, ³Mathematics and Computer Science, Eindhoven University of Technology, Eindhoven, Netherlands

The prevalence of sheet structure in the brain has been a debated issue since its proposal. This structure can be analyzed by means of the Lie bracket, which can be derived from diffusion MRI (dMRI) data. Due to the occurrence of noise, however, it is difficult to quantify to what degree the local structure effectively resembles a sheet. In this work, we propose a new and robust local measure based on the Lie bracket that can be interpreted as the sheet probability index (SPI).

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