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Abstract #0748

Magnetic resonance imaging of low-grade and high-grade gliomas at 7 Tesla

Bixia Chen1,2, Philipp Dammann1,2, Stefan Maderwald1, Soeren Johst1, Tobias Schoemberg1,2, Lale Umutlu1,3, Harald H. Quick1,4, Mark Edward Ladd1,5, Ulrich Sure2, and Karsten Henning Wrede1,2

1Erwin L. Hahn Institute for MRI, University of Duisburg-Essen, Essen, Germany, 2Department of Neurosurgery, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, 3Institute of Diagnostic and Interventional Radiology and Neuroradiology, University of Duisburg-Essen, Essen, Germany, 4High Field and Hybrid MR Imaging, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, 5Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Magnetic resonance imaging (MRI) plays a major role in diagnosis, multimodal treatment planning, and follow-up of low-grade and high-grade gliomas. In this prospective study, 24 patients were intra-individually examined at 3 Tesla (T) and 7T utilizing MPRAGE, T2 TSE, T2 FLAIR, and SWI sequences. Image evaluation had special focus on intra-tumoral structures, vascularization, intra-lesional hemorrhages, and contrast uptake. At 7T, intra-tumoral structures were depicted in excellent image quality. Especially SWI was superior at 7T compared to 3T and revealed microhemorrhages and vascularization patterns correlating with histopathology, possibly providing an additional imaging predictor for future grading of malignant gliomas.

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Abstract