Abstract #0736

Quantitating polyunsaturated fatty acids in neonates with hypoxic-ischemic brain injury

Jessica Lee Wisnowski^1,2, Aaron J Reitman^3,4, Tai-Wei Lee Wu³, Eugenia Ho⁵, Claire McLean⁶, Douglas Lee Vanderbilt⁶, Marvin D Nelson¹, Ashok Panigrahy⁷, Philippe Lee Friedlich^3,8, and Stefan Lee Bluml¹

¹Radiology, Children's Hospital Los Angeles, Los Angeles, CA, United States, ²Rudi Schulte Research Institute, Santa Barbara, CA, United States, ³Center for Fetal and Neonatal Medicine, Children's Hospital Los Angeles, Los Angeles, CA, United States, ⁴Division of Neonatal Medicine, LAC + USC Medical Center, Los Angeles, CA, United States, ⁵Division of Child Neurology, Children's Hospital Los Angeles, Los Angeles, CA, United States, ⁶Children's Hospital Los Angeles, Los Angeles, CA, United States, ⁷Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States, ⁸Division of Neonatal Medicine, University of Southern California, Los Angeles, CA, United States

Polyunsaturated fatty acids (PUFA) are endogenous components of cellular membranes and a potential biomarker for apoptosis following hypoxic-ischemic (HI) brain injury. Prior studies have applied ¹H-MRS techniques for quantifying PUFA in human carcinomas. Here, using a retrospective dataset of 1,046 neonatal ¹H-MRS spectra, we demonstrate that PUFA can be routinely characterized in newborns using a modified LCModel (Provencher, Inc) pipeline.

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