Andreas Pohlmann1, Karen Arakelyan1,2, Leili Riazy1, Till Huelnhagen1, Stefanie Kox1, Kathleen Cantow2, Sonia Waiczies1, Bert Flemming2, Erdmann Seeliger2, and Thoralf Niendorf1
1Berlin Ultrahigh Field Facility, Max Delbrueck Center for Molecular Medicine, Berlin, Germany, 2Institute of Physiology, Charite Universitaetsmedizin, Berlin, Germany
Acute kidney injuries are often characterized by tissue oxygen hypoxia. T2*-mapping
permits probing renal oxygenation but provides a surrogate rather than a
quantitative measure of oxygen saturation. The link between pO2 and
T2* is influenced by changes in blood volume fraction (BVf). Monitoring
BVf in combination with recently developed quantitative BOLD approaches could permit
unambiguous interpretation of renal T2*. To test the feasibility of this new
approach we monitored renal T2*/T2 during baseline and
short periods of venous occlusion. This was performed in the same animal under
naïve conditions and again with USPIO to permit estimation of BVf and SO2.
