Abstract #0707

Magnetic Resonance Elastography (MRE) for the assessment of renal allograft function

Jing Guo¹, Stephan Marticorena¹, Florian Dittmann¹, Andreas Fehlner¹, Sebastian Hirsch¹, Thomas Fischer¹, Jürgen Braun², and Ingolf Sack¹

¹Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ²Department of Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany

In vivo assessment of the renal allograft function post kidney transplantation is challenging. We here demonstrate that multifrequency MR elastography (MMRE) can detect renal allograft dysfunction with good diagnostic accuracy (AUROC:0.91 [95% CI 0.80-1.02; p < 0.001]). Renal stiffness is significantly lower in dysfunctional transplant kidney and correlates moderately with glomerular filtration rate and resistive index. MMRE may serve as a non-invasive imaging maker to detect renal allograft dysfunction in an early stage and to monitor renal allograft function longitudinally.

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