Abstract #0685

Quantitative Susceptibility Mapping for the Evaluation of Subcortical Iron Abnormality in Parkinson’s Disease with Dementia

Darrell Ting Hung Li¹, Edward Sai Kam Hui¹, Queenie Chan², Nailin Yao³, Siew-eng Chua⁴, Grainne M. McAlonan^4,5, Shu Leong Ho⁶, and Henry Ka Fung Mak¹

¹Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, ²Philips Healthcare, Hong Kong, Hong Kong, ³Department of Psychiatry, Yale University, New Haven, CT, United States, ⁴Department of Psychiatry, The University of Hong Kong, Hong Kong, Hong Kong, ⁵Department of Forensic and Neurodevelopmental Science, King’s College London, London, United Kingdom, ⁶Department of Medicine, The University of Hong Kong, Hong Kong, Hong Kong

Parkinson’s disease (PD) patients may develop other non-motor comorbidities when the disease progress. While increased nigral iron was considered as a biomarker of the disease, it was also believed that iron deposition is associated with the development of other non-motor symptoms. In this study, magnetic susceptibility as a surrogate of iron concentration was measured in six major subcortical brain regions on the QSM images. Increased magnetic susceptibilities were observed in hippocampus and amygdala of the PD patients with dementia, suggesting a possible association of iron with the development of dementia symptom in late stage of PD.

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