Quantitative and Functional Assessment of Red and Yellow Bone Marrow Using PET-MR Imaging
Chuan Huang1,2, Anuradha Janardhanan1,3, and Mark Schweitzer1
1Radiology, Stony Brook Medicine, Stony Brook, NY, United States, 2Psychiatry, Stony Brook Medicine, Stony Brook, NY, United States, 3Diagnostic Imaging, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia
Understanding the
distribution of red marrow is important for various hematopoetic diseases and
especially osseous metastases as areas of red marrow are the primary sites for
hematogenous seeding of tumor cells, accounting for approximately 90% of
skeletal metastases. Using a simultaneous PET-MR we sought to evaluate
voxel of red marrow in the femora
and pelvis using fat/water sequences correlated with FDG PET uptake. This quantitative assessment of red and yellow marrow was
done in specific anatomic subregions.
The
bone marrow composition and metabolism were found to be symmetric in each
individual. Good correlation between SUV and %red were found for each ROI among
all subjects. The metabolism (FDG uptake) was found to be different for the ROIs
with the same amount of red marrow. Further research will study whether this
leads to higher chance of tumor seeding.
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