Abstract #0655

A Novel Prostate DCE-MRI Flow Phantom for the Quantitative Evaluation of Pharmacokinetic Parameters

Silvin P. Knight¹, Jacinta E. Browne², James F. Meaney¹, David S. Smith³, and Andrew J. Fagan¹

¹National Centre for Advanced Medical Imaging (CAMI), St James Hospital / School of Medicine, Trinity College University of Dublin, Dublin, Ireland, ²School of Physics, Medical Ultrasound Group, Dublin Institute of Technology, Dublin, Ireland, ³Institute of Imaging Science / Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States

A method is lacking to comprehensively validate and optimise the ability of prostate DCE-MRI techniques to accurately measure pharmacokinetic (PK) parameters. We present a novel flow phantom capable of simultaneously producing two measurable, reproducible, and known arbitrarily-shaped contrast time-intensity curves, from which PK parameters can be derived. K^trans values were derived from MR data acquired at different temporal resolutions (2.3-20.3s) and were found to differ by -8.1% to -44.6%, when compared to calibrated ‘truth estimate’ values, with the lowest variance measured at a temporal resolution of 6.8s. The phantom can be used to help establish robust DCE-MRI prostate protocols.

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