Arterial transit time (ATT) heterogeneity in calf muscle: how DCE studies reveal a critical challenge for arterial spin labeling (ASL) acquisition
Jeff L. Zhang1, Christopher Hanrahan1, Christopher C. Conlin1, Corey Hart2, Gwenael Layec2, Kristi Carlston1, Daniel Kim1, Michelle Mueller3, and Vivian S. Lee1
1Radiology, University of Utah, Salt Lake City, UT, United States, 2Internal Medicine, University of Utah, Salt Lake City, UT, United States, 3Vascular surgery, University of Utah, Salt Lake City, UT, United States
One major challenge for measuring exercise perfusion of skeletal muscle
with ASL is the potential heterogeneity of arterial transit time (ATT) across
the muscle. In this study, we used reliable DCE MRI technique to measure ATT of
calf muscle in both healthy controls and peripheral artery disease patients and
after plantar flexion of different loads. Our study showed that ATT of calf
muscle varied with multiple factors, including muscle group, exercise load and
healthy status, and had a wide range of 0~4 sec. The result suggests the
necessity of performing calf-muscle ASL with multiple different post-labeling
delays.
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