A 3-Dimensional Microvascular Phantom for Perfusion Imaging
Thomas Gaass1,2, Moritz Schneider1, Michael Ingrisch1, Julia Herzen3, and Julien Dinkel1,2
1Institute for Clinical Radiology, Ludwig-Maximilians University, Munich, Germany, 2Comprehensive Pneumology Center, German Center for Lung Research, Munich, Germany, 3Department of Physics, Technische Universität München, Munich, Germany
The
presented work demonstrates the applicability of a dedicated 3-dimensional phantom as a
realistic MR- and CT-compatible phantom for microvascular perfusion simulation. The device constructed
using resin-embedded, melt-spun, sacrificial sugar structures was examined using dynamic contrast enhanced MRI. Parameters, such as flow and volume fraction gained from deconvolving the signal enhancement curve showed very good agreement with the pre-set perfusion parameters. The presented phantom showed great potential in realistically simulating the capillary bed and can
potentially serve as a quality insurance device for quantitative dynamic
contrast enhanced MRI in the future.
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