Tung-Lin Wu1,2, Feng Wang1,3, Li Min Chen1,3, Adam W. Anderson1,2,3, Zhaohua Ding1,3, and John C. Gore1,2,3
1Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, 2Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 3Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States
We previously reported the first evidence of
anisotropic rsfMRI-BOLD signals in white matter which appear to reflect a
functional structure not previously detected. To prove these signals have a
functional basis, we performed imaging of live squirrel monkeys under different
baselines of neural activity by altering anesthesia levels. Specifically, we compared
how different anesthesia levels modulate fractional power and spatio-temporal
correlation tensors in white matter. Our results demonstrate that low frequency
BOLD signal fluctuations behave similarly in grey and white matter. This indicates
that anisotropic rsfMRI-BOLD signals in white matter encode neural activity.
