Abstract #0562

Age-related Magnetic Susceptibility in the Deep Gray Nuclei from 1 month to 6 Years: Comparison between Quantitative Susceptibility and R2* Mapping

Ning Ning¹, Peng Wu², Xianjun Li³, Yajie Hu³, Weishan Zhang¹, Lei Zhang¹, Sung-Min Gho⁴, Dong-Hyun Kim⁴, Hua Guo², and Jian Yang^1,3

¹Department of Diagnostic Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China, People's Republic of, ²Department of Biomedical Engineering, Tsinghua University, Beijing, China, People's Republic of, ³Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China, People's Republic of, ⁴Department of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea, Republic of

To observe the age-related susceptibility changes in the deep gray nuclei and assess the superiority of the quantitative susceptibility mapping(QSM) and effective transverse relaxation rate(R2*) for quantifying the iron deposits in children. 87 subjects(1M-6Y) were enrolled. The susceptibility in QSM and R2* values exhibited positive correlations with age and the reference iron concentrations calculated using an empirical equation. The correlation of the susceptibility with the iron is higher than the R2* with it. QSM may provide a more promising and reliable tool for assessment of iron content in children’s deep gray nuclei, even in the regions with lower iron content.

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