Abstract #0534

Impact of Inter-lobular Fat on the Repeatability of Pancreatic Fat Fraction Measurement by MRI.

Adam Jaster¹, Ivan Pedrosa^1,2, Robert E. Lenkinski^1,2, Ildiko Lingvay^3,4, and Takeshi Yokoo^1,2

¹Radiology, UT Southwestern Medical Center, Dallas, TX, United States, ²Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, ³Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States, ⁴Clinical Sciences, UT Southwestern Medical Center, Dallas, TX, United States

In pancreatic steatosis, fat accumulates within intra-lobular (parenchyma) and inter-lobular (adipose) tissue. Regions of interest (ROIs) placed in pancreas include heterogeneous population of pixels of lower-fat intra-lobular tissue, higher-fat inter-lobular tissue, and admixture of the two by partial volume effects. In this study of 21 subjects with insulin-dependent type 2 diabetes, we investigated the impact of inter-lobular fat on the repeatability of pancreatic fat fraction (FF) measurement by multiecho gradient-echo MRI. We found that the mean FF measurement within segmented pancreatic ROI is highly repeatable with intraclass correlation of 0.965 after exclusion of high-fat (FF≥50%) pixels contaminated by inter-lobular fat.

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