Franziska Albers1, Florian Schmid1, Lydia Wachsmuth1, and Cornelius Faber1
With the
line scanning technique BOLD responses can be recorded with 50 ms temporal resolution.
Here line scanning fMRI was combined with optogenetic stimulation of excitatory
neurons in rat somatosensory cortex. The light for optogenetic stimulation was
delivered by an optical fiber implanted in the brain. It was possible to
compare BOLD responses upon optogenetic and sensory stimulation with high
temporal resolution and shorter times to reach half maximum were found for
optogenetic stimulation. Furthermore the spatial resolution offered the
possibility to observe cortical layer-specific BOLD signals.
