Abiola Olatunde1, Taylor Fuss1, Phillip Zhe Sun1, Leo L Cheng1, and Peter Caravan1
Prostate
cancer (PCa) is the most frequently diagnosed malignancy in men worldwide. Previous
studies have indicated the utility of
spermine as a potential biomarker for prostate cancer;
however, quantifying spermine using MRS is difficult due to overlapping
chemical shifts of spermine with other metabolites. We used LnDOTP5-,
an anionic lanthanide macrocyclic complex, to form a stable ternary complex with
positively-charged spermine to selectively shift spermine MR resonances. Here
we report the affinity of different LnDOTP5- complexes for spermine
and the effect of complex formation on spermine MR resonances in both D2O
and serum solutions and intact human prostate tissue.
