Abstract #0465

In-Vivo Quantification of Myocardial Stiffness in Heart Failure with Preserved Ejection Fraction Using Magnetic Resonance Elastography: Assessment in a Porcine Model

Ria Mazumder^1,2, Samuel Schroeder^2,3, Xiaokui Mo⁴, Bradley D Clymer⁵, Richard D White^2,6, and Arunark Kolipaka^2,6

¹Department of Electrical and Computer Enginerring, The Ohio State University, Columbus, OH, United States, ²Department of Radiology, The Ohio State University, Columbus, OH, United States, ³Department of Mechanical Engineering, The Ohio State University, Columbus, OH, United States, ⁴Department of Biomedical Informatics, The Ohio State University, Columbus, OH, United States, ⁵Department of Electrical and Computer Engineering, The Ohio State University, Columbus, OH, United States, ⁶Department of Internal Medicine-Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH, United States

Left ventricular (LV) myocardial stiffness (MS) is elevated in heart failure with preserved ejection fraction (HFpEF) and hence has the potential to be used as a diagnostic tool. Current clinical techniques to estimate LV MS are invasive in nature and provides global stiffness measurements. Therefore, in this study, we implement cardiac magnetic resonance to investigate temporal alteration in LV MS over a two month period of disease progression in a porcine model induced with HFpEF. The alteration in LV MS is compared against change in mean LV pressure, LV thickness, circumferential strain and MRI relaxometry parameters.

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