xiaoyu jiang1, hua li1, jingping Xie1, ping zhao1, junzhong xu1, dineo khabele2, and John Gore1
1vanderbilt university institute of imaging science, nashville, TN, United States, 2vanderbilt university, nashville, TN, United States
Reliable and sensitive methods for assessing the response of tumors to
treatment are critical in rapid selection of the most appropriate therapy for
individual patients, and development of novel therapies. Temporal diffusion
spectroscopy, which measures the variation of apparent diffusion coefficient
(ADC) over a range of effective diffusion times, is proposed to measure tumor
microstructural variations in response to chemotherapy. The proposed method is
shown to detect the increase in cell size in response to the
antimitotic-treatment in both well-characterized cell culture and solid tumors in vivo. The MR observations are
supported by flow cytometric, microscopic, and histological analysis.
