Joana Pinto1, Pedro Vilela2, Michael A. Chappell3, and Patrícia Figueiredo1
1ISR-Lisboa/LARSyS and Department of Bioengineering, Instituto Superior Técnico – Universidade de Lisboa, Lisbon, Portugal, 2Imaging Department, Hospital da Luz, Lisbon, Portugal, 3Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom
Absolute CBF
quantification using ASL requires the normalization of the control-label
difference images by the equilibrium magnetization, M0. A voxelwise
calibration method is currently recommended for single post-labelling-delay
(PLD) PCASL. However, the impact of using an M0t map obtained directly
from the ASL data, with no need for an extra scan, by fitting a
saturation-recovery curve to the control image time-series in multiple-PLD PASL
remains to be investigated. Here, we show that, using this type of acquisition,
voxelwise calibration significantly reduced inter- and intra-subject variability in gray matter CBF measurements
relative to methods based on a reference tissue.
