Qiu Ge1, Wei Peng1, Yong Zhang2, Yu-Feng Zhang1, Thomas Liu3, Xuchu Weng1, and Ze Wang1
1Hangzhou Normal University, Hangzhou, China, People's Republic of, 2GE Healthcare, MR Research China, Beijing, Shanghai, China, People's Republic of, 3University of California San Diego, San Diego, CA, United States
MRI-identified short-term brain
tissue changes have been in debate because of the lack of solid evidence of
neurogenesis. Cerebral blood flow (CBF) has been traced as one contributing
factor. We used caffeine to modulate CBF and to subsequently examine brain
tissue change using MRI. Both CBF reduction and grey matter decrease were
observed after caffeine ingestion, which were further related to each other in
some brain regions. The data provide direct evidence for the CBF contribution
to the short-term apparent tissue changes.
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