Abstract #0416

Optimized Cardiac CEST MRI for Assessment of Metabolic Activity in the Heart

Zhengwei Zhou^1,2, Yuhua Chen³, Yibin Xie¹, Christopher Nguyen¹, Mu Zeng⁴, James Dawkins⁵, Zhanming Fan⁴, Eduardo Marbán⁵, and Debiao Li^1,2,5

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, ³Department of Computer and Information Science, University of Pennsylvania, Philadelphia, PA, United States, ⁴Department of Radiology, Anzhen Hospital, Capital Medical University, Beijing, China, People's Republic of, ⁵Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States

In this work, we developed an optimized cardiac CEST method to detect myocardial metabolic change with significantly reduced scan time. Our initial results in porcine model with chronic myocardial infarction show that scar region has lower metabolic activity compared to healthy myocardium, using LGE as reference. This study also shows the feasibility of cardiac CEST imaging in a patient, for the first time.

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