Feliks Kogan1, Audrey Fan1, Emily McWalter1, Edwin Oei2, Andrew Quon1, and Garry Gold1
1Radiology, Stanford University, Stanford, CA, United States, 2Radiology, Erasmus Medical Center, Rotterdam, Netherlands
Osteoarthritis
(OA) is a debilitating disease that affects 27 million
Americans, causing pain,
stiffness and loss of mobility. Simultaneous PET-MR imaging provides an opportunity
to combine metabolic information regarding bone remodeling with high resolution
images on MR. This work demonstrates that simultaneous 18F-fluoride
PET/MR may provide additional metabolic information regarding bone pathology seen
on conventional MR. This will allow for a better understanding of the role of
bone degeneration in OA disease processes. Additionally, 18F-fluoride
PET/MR may detect knee abnormalities unseen on MRI alone and is a promising
tool for detection of early metabolic changes in OA.
