Abstract #0361

Discrimination of Hepatic Inflammation and Fibrosis with Magnetic Resonance Elastography

Meng Yin¹, Kevin J. Glaser¹, Harmeet Malhi², Amy Mauer², Anuradha Krishnan², Taofic Mounajjed³, Jason Bakeberg⁴, Christopher Ward⁴, Ruisi Wang², Douglas Simonnetto², Shennen Mao⁵, Jaime Glorioso⁵, Faysal Elgilani⁶, Vijay Shah², Scott Nyberg⁶, Armando Manduca¹, and Richard L. Ehman¹

¹Radiology, Mayo Clinic, Rochester, MN, United States, ²Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States, ³Pathology, Mayo Clinic, Rochester, MN, United States, ⁴Nephrology and Hypertension Research, Mayo Clinic, Rochester, MN, United States, ⁵Surgery, Mayo Clinic, Rochester, MN, United States, ⁶Transplant Center, Mayo Clinic, Rochester, MN, United States

To investigate the utility of MRE-derived mechanical properties in discriminating hepatic inflammation and fibrosis in early-stage of chronic liver diseases, we performed multifrequency 3D MRE on five different in vivo animal models with chronic liver diseases. Liver stiffness and phase angle derived from complex shear modulus were selected for evaluation. Results demonstrated distinct and potentially characteristic changes in these mechanical properties with hepatic inflammation, fibrosis and increased portal pressure. The findings offer preliminary evidence of the potential to extend MRE to distinguish and independently assess necroinflammatory and fibrotic processes in the early phase of chronic liver diseases.

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