1Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, U.S. Food and Drug Administration, Silver Spring, MD, United States, 2Department of Information Engineering, Electronics and Telecommunications, University of Rome "Sapienza", Rome, Italy, 3MR:comp GmbH, Gelsenkirchen, Germany, 4IT'IS foundation, Zurich, Switzerland, 5ANSYS, Inc., Canonsburg, PA, United States, 6Department of Information Technology and Electrical Engineering, ETH, Zurich, Switzerland