Joanes Grandjean1, Valerio Zerbi2, Nicole Wenderoth2, and Markus Rudin1
Connectomics
holds promise to foster our understanding of the healthy and disordered brain.
MRI has been the method of choice for such analysis, combining diffusion
weighted with functional imaging to resolve structural and functional
connectivity, respectively. However,
both methods are indirect measures prone to bias and artifacts. In mice,
structural connectivity has been reconstructed with high spatial resolution by
mapping the distribution of viral tracers following local injections at
multiple sites offering a unique opportunity to compare functional connectivity
with detailed mono-synaptic projections. Such comparisons should help bridging
functional and structural connectivity in rodents with implications for human
studies.
