Implementing single-shot quantitative CEST/T1ρ measurements using bSSFPX
Shu Zhang1, Robert E Lenkinski1,2, and Elena Vinogradov1,2
1Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States
Recently
properties of bSSFP were explored to detect exchange processes (bSSFPX),
similar to CEST or off-resonance T1ρ experiments.
We expand the study and implement a transient bSSFPX experiment that acquires
bSSFP spectra continuously as the effective saturation time increases, allowing
observation of the approach of magnetization to the steady state in a single
shot. The magnetization dynamic is governed by the effective field and
relaxation times parallel or perpendicular to it. Work is in progress to derive an exact
quantification model. The method leads to fast acquisition of time-dependent
data and may speed up QUEST-like quantification of the exchange processes.
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