Abstract #0284

Neuroimaging of Acute Ebola Virus Disease in a Non-Human Primate Model

Margaret R. Lentz¹, Jeffery R. Solomon², Srikanth Yellayi¹, Richard Bennett¹, Dawn Traynor¹, David Thomasson¹, Anna Honko¹, Lisa Hensley¹, and Peter B. Jahrling^1,3

¹Integrated Research Facility, NIAID, National Institutes of Health, Frederick, MD, United States, ²Clinical Research Directorate/Clinical Monitoring Research Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, United States, ³Emerging Viral Pathogens Section, NIAID, National Institutes of Health, Frederick, MD, United States

The purpose of this study was to use MRI to assess alterations in the brain that occur in rhesus macaques infected with a variant of the Ebola virus (EBOV) isolated from the most recent outbreak. EBOV was found to induce signal alterations in susceptibility weighted imaging (SWI) along vasculature that correlate to venous congestion and perivascular hemorrhage. The use of SWI or other gradient echo based methods to examine vascular changes may be of interest when examining survivors of Ebola. Additionally, the identification of non-invasive imaging biomarkers of EBOV disease progression could help in development of medical countermeasures.

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