Jeff L. Zhang1, Christopher Hanrahan1, Christopher C. Conlin1, Corey Hart2, Gwenael Layec2, Kristi Carlston1, Daniel Kim1, Michelle Mueller3, and Vivian S. Lee1
1Radiology, University of Utah, Salt Lake City, UT, United States, 2Internal Medicine, University of Utah, Salt Lake City, UT, United States, 3Vascular surgery, University of Utah, Salt Lake City, UT, United States
Noninvasive mapping of calf muscle perfusion with high spatial
resolution has potential for assessing the severity of peripheral artery
disease (PAD) and studying associated capillary density abnormality. We tested
our novel DCE-MRI method to measure calf muscle hyperemia stimulated by plantar
flexion at three different workloads. Increases in exercise load caused
increased total perfusion in gastrocnemius, with a heterogeneous pattern at
medium load and homogeneous at higher load. Perfusion in soleus did not
increase until very heavy load of 16 lbs. DCE-MRI provides high spatial
resolution measurement of post-exercise muscle perfusion.
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