yue cheng1, Li-xiang Huang1, Shuang-shuang Xie1, Tian-yi Qian2, and Wen Shen1
1Tianjin First Central Hospital, Tianjin, China, People's Republic of, 2Siemens Healthcare, MR Collaborations NE Asia, Beijing, China, People's Republic of
In
this study, we evaluated brain activity changes in cirrhotic patients referred
for liver transplantation (LT). Twenty cirrhotic patients and 25 healthy
controls were included. Amplitude of low-frequency fluctuation (ALFF) values were
compared between cirrhotic patients (pre- and post-LT) and healthy controls as well
as patients pre- and post-LT. In cirrhotic patients, decreased ALFF in most
brain regions can be reversed one month after LT, and the increased ALFF in
temporal and frontal lobe may also return to normal. The reduced ALFF in the
right supplementary motor area, inferior parietal lobule and calcarine
persisted. One month after LT, the spontaneous brain activity partially renormalized,
but complete cognitive function
restoration may need a longer time.
