Abstract #0195

In Vivo Conductivity Imaging of Rat Tumor Model Using MRI

Jiaen Liu¹, Qi Shao¹, Yicun Wang¹, Gregor Adriany², John Bischof³, Pierre-Francois Van de Moortele², and Bin He^1,4

¹Biomedical Engineering, Univeristy of Minnesota, Minneapolis, MN, United States, ²Center for Magnetic Resonance Research, Univeristy of Minnesota, Minneapolis, MN, United States, ³Mechanical Engineering, Univeristy of Minnesota, Minneapolis, MN, United States, ⁴Institute for Engineering in Medicine, Univeristy of Minnesota, Minneapolis, MN, United States

Noninvasive in vivo imaging of the tissue conductivity has great potential in cancer diagnosis. Recently, electrical properties tomography (EPT) has been investigated with increasing effort to noninvasively image tissue conductivity in vivo using MRI. A preclinical method for imaging tumor conductivity can be valuable for understanding tumor development and associated conductivity change due to fundamental molecular and cellular reasons. In this study, tumor conductivity was studied based on a xenograft rat tumor model using a small animal EPT system. The result showed elevated conductivity in cancerous tissue compared to healthy tissue, suggesting the clinical value of EPT for tumor diagnosis.

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