CEST Metrics for Assessing Early Response to Stereotactic Radiosurgery in Human Brain Metastases
Kimberly L. Desmond1,2, Hatef Mehrabian1,2, Arjun Sahgal1,3, Hany Soliman1,3, and Greg J. Stanisz1,2
1Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 2Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3Radiation Oncology, Odette Cancer Centre, Toronto, ON, Canada
Chemical exchange saturation transfer (CEST) spectra were collected at three timepoints following stereotactic radiosurgery (SRS). The magnetization transfer ratio (MTR) and CEST peak properties were evaluated at the offset frequencies of the NOE, amide and amine pools in the lesion and in the surrounding tissue. Positive correlation was found between changes in NOE peak amplitude and amide MTR at 1 week post-therapy and tumour volume change at one month post-therapy, while negative correlation was found between amide peak width and NOE peak amplitude at the pre-treatment timepoint with volume change at one month post-therapy (p<0.1).
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