In Vivo Visualization of Iron-Rich Amyloid Plaques In Cholesterol-Fed Rabbits using Clinical Field-Strength Magnetic Resonance Imaging
Yuanxin Chen1, Yong Wang1,2, Kem A Rogers1, John A Ronald1, and Brian K Rutt3
1Western University, London, ON, Canada, 2Lawson Health Research Institute, London, ON, Canada, 3Stanford University, Stanford, CA, United States
Hypercholesterolemia
is a risk factor for AD and promotes increased production of beta-amyloid
protein. Our lab has developed a rabbit model of AD by enriching the diets of
rabbits with low amounts of cholesterol. In this study, we combined this
cholesterol-fed rabbit model of AD with iron-sensitive, high-resolution MRI and
demonstrated non-invasive in vivo visualization of AD
plaques throughout the brains of these animals. The imaging techniques have
been developed and optimized using a clinical field strength scanner (3T), which is an important step towards clinical application in human AD
patients.
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